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Point mutations resulting in loss of function were found in a panel of gastrointestinal (25%), lung (20%) and breast (13%) carcinomas, with 11 of the 14 mutations resulting in truncations of the receptor. Mutations at the 5'-end of the receptor were found in >50% of breast, gastrointestinal and colorectal carcinomas, indicating a possible tumour-suppressor role of RON2. The inhibitory effect of bombesin on gastric and pancreatic cell growth is limited by the presence of bombesin-like peptides, but can be mimicked by activation of the G-protein coupled receptor RON2. Thus, RON2 appears to be a molecular target for tumour growth and, as RON2 is restricted in its expression to epithelial cells, it may also function as a tumour suppressor in epithelial cancers.A series of photos of the Rev. Clementa Pinckney and Rev. DePayne Middleton-Doctor before and after the attack on the Emanuel AME Church in Charleston, S.C. (The Washington Post) The Rev. Clementa C. 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